Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.

Shi, Wuxian; Ting, Li-Min; Kicska, Gregory A; Lewandowicz, Andrzej; Tyler, Peter C; Evans, Gary B; Furneaux, Richard H; Kim, Kami; Almo, Steve C; Schramm, Vern L

Shi, Wuxian; Ting, Li-Min; Kicska, Gregory A; Lewandowicz, Andrzej; Tyler, Peter C; Evans, Gary B; Furneaux, Richard H; Kim, Kami; Almo, Steve C; Schramm, Vern L.

Affiliation

Shi W; Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA.

J Biol Chem ; 279(18): 18103-6, 2004 Apr 30.

Article in En | MEDLINE | ID: mdl-14982926

Subject(s)

Methylthioinosine/analogs & derivatives; Plasmodium falciparum/enzymology; Purine-Nucleoside Phosphorylase/chemistry; Purine-Nucleoside Phosphorylase/metabolism; Animals; Catalysis; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors/chemistry; Humans; Hydrophobic and Hydrophilic Interactions; Methylthioinosine/metabolism; Molecular Structure; Purine Nucleosides; Purine-Nucleoside Phosphorylase/antagonists & inhibitors; Pyrimidinones/chemistry; Pyrroles/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Purine-Nucleoside Phosphorylase / Methylthioinosine Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2004 Document type: Article Affiliation country: United States

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