Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor.

Morimoto, Alyssa M; Tan, Nguyen; West, Kristina; McArthur, Grant; Toner, Guy C; Manning, William C; Smolich, Beverly D; Cherrington, Julie M

Morimoto, Alyssa M; Tan, Nguyen; West, Kristina; McArthur, Grant; Toner, Guy C; Manning, William C; Smolich, Beverly D; Cherrington, Julie M.

Affiliation

Morimoto AM; Department of Preclinical Research and Exploratory Development, SUGEN, Inc., 230 E Grand Ave., South San Francisco, CA 94080, USA. morimoto@gene.com

Oncogene ; 23(8): 1618-26, 2004 Feb 26.

Article in En | MEDLINE | ID: mdl-14985702

Subject(s)

Cadherins/metabolism; Colonic Neoplasms/metabolism; Enzyme Inhibitors/therapeutic use; Indoles/therapeutic use; Pyrroles/therapeutic use; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors; Animals; Biomarkers; Cadherins/drug effects; Cell Line, Tumor; Feasibility Studies; Female; Gene Expression Profiling/methods; Humans; Immunohistochemistry; Mice; Mice, Nude; Neoplasm Transplantation; Sunitinib; Transplantation, Heterologous

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Cadherins / Receptor Protein-Tyrosine Kinases / Colonic Neoplasms / Enzyme Inhibitors / Indoles Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2004 Document type: Article Affiliation country: United States Country of publication: United kingdom

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