Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro.

Moulharat, N; Lesur, C; Thomas, M; Rolland-Valognes, G; Pastoureau, P; Anract, P; De Ceuninck, F; Sabatini, M

Moulharat, N; Lesur, C; Thomas, M; Rolland-Valognes, G; Pastoureau, P; Anract, P; De Ceuninck, F; Sabatini, M.

Affiliation

Moulharat N; Division of Rheumatology, Institut de Recherches Servier, Suresnes, France.

Osteoarthritis Cartilage ; 12(4): 296-305, 2004 Apr.

Article in En | MEDLINE | ID: mdl-15023381

Subject(s)

Chondrocytes/drug effects; Metalloendopeptidases/biosynthesis; Osteoarthritis/metabolism; Proteoglycans/metabolism; Transforming Growth Factor beta/pharmacology; ADAM Proteins; ADAMTS4 Protein; Adolescent; Adult; Aged; Cartilage, Articular/metabolism; Cells, Cultured; Chondrocytes/metabolism; Endopeptidases/analysis; Female; Humans; Interleukin-1/pharmacology; Male; Matrix Metalloproteinases/analysis; Middle Aged; Procollagen N-Endopeptidase; Protein Denaturation/physiology; RNA, Messenger/analysis; Reverse Transcriptase Polymerase Chain Reaction/methods; Tumor Necrosis Factor-alpha/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Proteoglycans / Metalloendopeptidases / Transforming Growth Factor beta / Chondrocytes Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Osteoarthritis Cartilage Journal subject: ORTOPEDIA / REUMATOLOGIA Year: 2004 Document type: Article Affiliation country: France Country of publication: United kingdom

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