Antioxidative treatment reverses imbalances of nitric oxide synthase isoform expression and attenuates tissue-cGMP activation in diabetic rats.

Bojunga, Jörg; Dresar-Mayert, Birgit; Usadel, Klaus-Henning; Kusterer, Klaus; Zeuzem, Stefan

Bojunga, Jörg; Dresar-Mayert, Birgit; Usadel, Klaus-Henning; Kusterer, Klaus; Zeuzem, Stefan.

Affiliation

Bojunga J; Innere Medizin II, Medizinische Klinik und Poliklinik, Saarland University, Homburg/Saar, Germany. dr_bojunga@web.de

Biochem Biophys Res Commun ; 316(3): 771-80, 2004 Apr 09.

Article in En | MEDLINE | ID: mdl-15033467

Subject(s)

Antioxidants/pharmacology; Cyclic GMP/metabolism; Nitric Oxide Synthase/chemistry; Animals; Antioxidants/chemistry; Antioxidants/metabolism; Apoptosis; Blood Glucose/metabolism; DNA Primers/chemistry; Diabetes Mellitus, Experimental/metabolism; Down-Regulation; Immunohistochemistry; Male; Nitrates/chemistry; Nitric Oxide/metabolism; Nitric Oxide Synthase/metabolism; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites/chemistry; Oxidative Stress; Polymerase Chain Reaction; Protein Isoforms; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sulfhydryl Compounds/blood; Thioctic Acid/chemistry; Tissue Distribution; Up-Regulation

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Collection: 01-internacional Database: MEDLINE Main subject: Cyclic GMP / Nitric Oxide Synthase / Antioxidants Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2004 Document type: Article Affiliation country: Germany Country of publication: United States

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