A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins.

Thomas, K; Aalbers, M; Bannon, G A; Bartels, M; Dearman, R J; Esdaile, D J; Fu, T J; Glatt, C M; Hadfield, N; Hatzos, C; Hefle, S L; Heylings, J R; Goodman, R E; Henry, B; Herouet, C; Holsapple, M; Ladics, G S; Landry, T D; MacIntosh, S C; Rice, E A; Privalle, L S; Steiner, H Y; Teshima, R; Van Ree, R; Woolhiser, M; Zawodny, J

Thomas, K; Aalbers, M; Bannon, G A; Bartels, M; Dearman, R J; Esdaile, D J; Fu, T J; Glatt, C M; Hadfield, N; Hatzos, C; Hefle, S L; Heylings, J R; Goodman, R E; Henry, B; Herouet, C; Holsapple, M; Ladics, G S; Landry, T D; MacIntosh, S C; Rice, E A; Privalle, L S; Steiner, H Y; Teshima, R; Van Ree, R; Woolhiser, M; Zawodny, J.

Affiliation

Thomas K; ILSI Health and Environmental Sciences Institute, Washington, DC, USA. kthomas@ilsi.org

Regul Toxicol Pharmacol ; 39(2): 87-98, 2004 Apr.

Article in En | MEDLINE | ID: mdl-15041142

Subject(s)

Clinical Laboratory Techniques/standards; Pepsin A/chemistry; Proteins/chemistry; Digestion; Electrophoresis, Polyacrylamide Gel; Gastrointestinal Agents/chemistry; Hydrogen-Ion Concentration; Peptide Fragments/chemistry; Reproducibility of Results

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Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Pepsin A / Clinical Laboratory Techniques Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies Language: En Journal: Regul Toxicol Pharmacol Year: 2004 Document type: Article Affiliation country: United States

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