Inhibition of p38-mitogen-activated protein kinase may protect from clozapine-induced agranulocytosis.

Loeffler, Stefan; Fehsel, Karin; Krieger, Klaus; Henning, Uwe; Klimke, Ansgar

Loeffler, Stefan; Fehsel, Karin; Krieger, Klaus; Henning, Uwe; Klimke, Ansgar.

World J Biol Psychiatry ; 5(1): 54-5, 2004 Jan.

Article in En | MEDLINE | ID: mdl-15048637

Subject(s)

Agranulocytosis/chemically induced; Agranulocytosis/prevention & control; Clozapine/adverse effects; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Serotonin Antagonists/adverse effects; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Clozapine/therapeutic use; Genistein/administration & dosage; Genistein/pharmacology; Granulocyte Colony-Stimulating Factor/drug effects; Humans; Reactive Oxygen Species/metabolism; Schizophrenia/drug therapy; p38 Mitogen-Activated Protein Kinases

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Collection: 01-internacional Database: MEDLINE Main subject: Serotonin Antagonists / Clozapine / Mitogen-Activated Protein Kinases / Agranulocytosis Limits: Humans Language: En Journal: World J Biol Psychiatry Journal subject: PSIQUIATRIA Year: 2004 Document type: Article Country of publication: United kingdom

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