Sonographic findings in Beckwith-Wiedemann syndrome related to H19 hypermethylation.
Prenat Diagn
; 24(3): 165-8, 2004 Mar.
Article
in En
| MEDLINE
| ID: mdl-15057946
ABSTRACT
Beckwith-Wiedemann syndrome (BWS) is an overgrowth syndrome associated with congenital malformations and tumour predisposition. BWS results from variable mutations or epigenetic modifications of imprinted genes in the 11p15 chromosomal region. We present a fetus with mild general overgrowth and bilateral enlarged echogenic kidneys with loss of the corticomedullary differentiation in which prenatal diagnosis of BWS was suspected. The rest of the fetal anatomy and the amniotic fluid volume appeared normal. After termination of the pregnancy, molecular analysis confirmed the diagnosis of BWS by showing an isolated hypermethylation of the H19 gene.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Beckwith-Wiedemann Syndrome
/
Chromosomes, Human, Pair 11
/
Ultrasonography, Prenatal
/
DNA Methylation
/
RNA, Untranslated
/
Fetal Diseases
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Prenat Diagn
Year:
2004
Document type:
Article
Affiliation country:
France