Identification and determination of phase II nabumetone metabolites by high-performance liquid chromatography with photodiode array and mass spectrometric detection.

Nobilis, M; Holcapek, M; Kolárová, L; Kopecký, J; Kunes, M; Svoboda, Z; Kvetina, J

Nobilis, M; Holcapek, M; Kolárová, L; Kopecký, J; Kunes, M; Svoboda, Z; Kvetina, J.

Affiliation

Nobilis M; Institute of Experimental Biopharmaceutics, Joint Research Center of PRO.MED.CS Praha a.s. and Academy of Sciences of the Czech Republic, Heyrovského 1207, CZ-500 03 Hradec Králové, Czech Republic. nobilis@uebf.cas.cz

J Chromatogr A ; 1031(1-2): 229-36, 2004 Mar 26.

Article in En | MEDLINE | ID: mdl-15058587

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics; Butanones/pharmacokinetics; Animals; Anti-Inflammatory Agents, Non-Steroidal/urine; Bile/chemistry; Biotransformation; Butanones/urine; Chromatography, High Pressure Liquid; Data Display; Glucuronidase/chemistry; Intestines/chemistry; Mass Spectrometry; Nabumetone; Spectrometry, Mass, Electrospray Ionization; Sulfatases/chemistry; Swine; Swine, Miniature

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Collection: 01-internacional Database: MEDLINE Main subject: Butanones / Anti-Inflammatory Agents, Non-Steroidal Type of study: Diagnostic_studies / Guideline / Qualitative_research Limits: Animals Language: En Journal: J Chromatogr A Year: 2004 Document type: Article Affiliation country: Czech Republic Country of publication: Netherlands

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