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Collection of peripheral progenitor cells: a comparison between Amicus and Cobe-Spectra blood cell separators.
Adorno, Gaspare; Del Proposto, Gianpaolo; Palombi, Francesca; Bruno, Antonio; Ballatore, Giovanna; Postorino, Massimiliano; Tendas, Andrea; Del Poeta, Giovanni; Isacchi, Giancarlo; Amadori, Sergio.
Affiliation
  • Adorno G; Department of Immunohematology, Tor Vergata University of Rome, Viale Oxford, 81, 00133 Rome, Italy. medtrasf@libero.it
Transfus Apher Sci ; 30(2): 131-6, 2004 Apr.
Article in En | MEDLINE | ID: mdl-15062751
The authors compared the efficiency of two different blood cell separators (Amicus and Cobe-Spectra) in collecting peripheral blood progenitor cells for autologous or homologous transplantation. A total number of 129 procedures were performed, 36 with Spectra, 93 with Amicus. There was no difference between Spectra and Amicus efficiencies for CD34+ cell collection (46.685% vs 46.235%; p=n.s) but the platelet efficiencies were 17.31% and 12.54% respectively (p=0.04) and, if autologous and allogeneic collections were considered separately, a marked difference resulted in allogeneic platelet efficiency between 6 Spectra and 23 Amicus procedures (26.83% vs 8.68%, p=0.0004). The authors were able to demonstrate that in 70 Amicus autologous collections there was a different platelet efficiency, if peripheral count was considered: 12 procedures performed with a platelet count > 100 x 10(9)/l had a very low efficiency (6.86%), but this value increased if platelet count lowered (13.02% if between 100 and 50 x 10(9)/l, 22.63% if between 50 and 0 x 10(9)/l, 23 and 35 procedures respectively). The study is preliminary and the number of collections is little, but the overall data suggest that Spectra (AutoPBSC, V 6.0) and Amicus separators have the same efficiency for collecting CD34+ cells while Amicus procedures have a very low platelet contamination, especially with donors.
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Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Blood Component Removal / Cell Separation Limits: Humans Language: En Journal: Transfus Apher Sci Journal subject: HEMATOLOGIA Year: 2004 Document type: Article Affiliation country: Italy Country of publication: United kingdom
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Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Blood Component Removal / Cell Separation Limits: Humans Language: En Journal: Transfus Apher Sci Journal subject: HEMATOLOGIA Year: 2004 Document type: Article Affiliation country: Italy Country of publication: United kingdom