Potent and orally active ET(A) selective antagonists with 5,7-diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acid structures.

Yoshizumi, Takashi; Takahashi, Hirobumi; Ohtake, Norikazu; Jona, Hideki; Sato, Yoshiyuki; Kishino, Hiroyuki; Sakamoto, Toshihiro; Ozaki, Satoshi; Takahashi, Hiroyuki; Shibata, Yoshihiro; Ishii, Yasuyuki; Saito, Michiyasu; Okada, Megumu; Hayama, Takashi; Nishikibe, Masaru

Yoshizumi, Takashi; Takahashi, Hirobumi; Ohtake, Norikazu; Jona, Hideki; Sato, Yoshiyuki; Kishino, Hiroyuki; Sakamoto, Toshihiro; Ozaki, Satoshi; Takahashi, Hiroyuki; Shibata, Yoshihiro; Ishii, Yasuyuki; Saito, Michiyasu; Okada, Megumu; Hayama, Takashi; Nishikibe, Masaru.

Affiliation

Yoshizumi T; Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan. yoszmitk@banyu.co.jp

Bioorg Med Chem ; 12(9): 2139-50, 2004 May 01.

Article in En | MEDLINE | ID: mdl-15080914

Subject(s)

Carboxylic Acids/chemistry; Carboxylic Acids/pharmacology; Endothelin A Receptor Antagonists; Administration, Oral; Biological Availability; Carboxylic Acids/administration & dosage; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver/drug effects; Microsomes, Liver/enzymology; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Carboxylic Acids / Endothelin A Receptor Antagonists Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2004 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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