Effects of acute hypercholesterolemia on blood pressure and pressor response to norepinephrine in rats.
Blood Press
; 13(1): 56-61, 2004.
Article
in En
| MEDLINE
| ID: mdl-15083642
ABSTRACT
To examine if high cholesterol in blood acutely affects the blood pressure, we partly exchanged the blood of normal rats for that of hypercholesterolemic rats. Male Sprague-Dawley rats were fed for 8 weeks with a high-cholesterol diet (4% cholesterol; HC) or a normal diet (NC). The rats were catheterized; and blood of animals in NC was partly exchanged with that of HC (N-H) or other animals in NC (N-N). Systolic blood pressure (SBP) and the pressor response to norepinephrine (NE) in N-H were compared with those of N-N. Serum lipids and malondialdehyde (MDA), and urinary excretion of protein (UP) and NE (UNE) were determined. After 8 weeks, SBP, serum total cholesterol (TC), MDA, UP and UNE were higher in the HC. Blood exchange caused an increase in TC, MDA and SBP in only the N-H. Increases in SBP caused by NE injection were rather less in the N-H than in the N-N. The blood pressure increase induced by a high-cholesterol diet seemed to be caused by certain factors in the blood of hypercholesterolemic rats. Excessive lipid oxidation induced by hypercholesterolemia may be involved in the blood pressure elevation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Pressure
/
Norepinephrine
/
Hypercholesterolemia
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Blood Press
Journal subject:
ANGIOLOGIA
Year:
2004
Document type:
Article
Affiliation country:
Japan