Semecarpus anacardium L, nuts inhibit lipopolysaccharide induced NO production in rat macrophages along with its hypolipidemic property.
Indian J Exp Biol
; 42(4): 432-6, 2004 Apr.
Article
in En
| MEDLINE
| ID: mdl-15088696
ABSTRACT
Traditionally S. anacardium is used for rejuvenation, rheumatoid arthritis, fever and neurological disorders. In the present study it was observed that a fraction of S. anacacrdium at dose of 1 mg/100 g body wt, significantly reduced serum cholesterol from 378.87 mg/dl in the rats fed with atherogenic diet (AD) to 197.99 mg/dl (45-52%) in the rats fed with AD diet and increased serum HDL-cholesterol (33-37%). The same fraction also inhibited LPS induced NO production in the culture activated rat peritoneal macrophages in the dose dependent manner with IC50 value at 50 ng/ml of the culture medium. The drug in the above doses was completely safe and non-toxic, (no change in the enzymes), to liver and kidney functions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lipopolysaccharides
/
Macrophages, Peritoneal
/
Semecarpus
/
Hypolipidemic Agents
/
Nitric Oxide
Limits:
Animals
Language:
En
Journal:
Indian J Exp Biol
Year:
2004
Document type:
Article
Affiliation country:
India