Enhanced oral bioavailability of a poorly water soluble drug PNU-91325 by supersaturatable formulations.

Gao, Ping; Guyton, Michael E; Huang, Tiehua; Bauer, Juliane M; Stefanski, Kevin J; Lu, Qun

Gao, Ping; Guyton, Michael E; Huang, Tiehua; Bauer, Juliane M; Stefanski, Kevin J; Lu, Qun.

Affiliation

Gao P; Worldwide Pharmaceutical Sciences, Pfizer Inc., Kalamazoo, Michigan 49007, USA. ping.gao@pfizer.com

Drug Dev Ind Pharm ; 30(2): 221-9, 2004 Feb.

Article in En | MEDLINE | ID: mdl-15089057

Subject(s)

Hypoglycemic Agents/pharmacokinetics; Pyridines/administration & dosage; Pyridines/chemistry; Adjuvants, Pharmaceutic; Administration, Oral; Animals; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Drug Delivery Systems; Hypoglycemic Agents/administration & dosage; Hypromellose Derivatives; In Vitro Techniques; Insulin/metabolism; Insulin Secretion; Methylcellulose/analogs & derivatives; Pharmaceutical Vehicles; Pyridines/blood; Solubility

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Hypoglycemic Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Drug Dev Ind Pharm Year: 2004 Document type: Article Affiliation country: United States

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