The human melanoma cell line MelJuSo secretes bioactive FasL and APO2L/TRAIL on the surface of microvesicles. Possible contribution to tumor counterattack.

Martínez-Lorenzo, María José; Anel, Alberto; Alava, María A; Piñeiro, Andrés; Naval, Javier; Lasierra, Pilar; Larrad, Luis

Martínez-Lorenzo, María José; Anel, Alberto; Alava, María A; Piñeiro, Andrés; Naval, Javier; Lasierra, Pilar; Larrad, Luis.

Affiliation

Martínez-Lorenzo MJ; Servicio de Inmunología, Hospital Clínico Universitario Lozano Blesa, E-50009, Zaragoza, Spain. linm@hcu-lblesa.es

Exp Cell Res ; 295(2): 315-29, 2004 May 01.

Article in En | MEDLINE | ID: mdl-15093732

Subject(s)

Melanoma/metabolism; Membrane Glycoproteins/metabolism; Secretory Vesicles/metabolism; T-Lymphocytes/cytology; Tumor Necrosis Factor-alpha/metabolism; fas Receptor/metabolism; Actins/metabolism; Apoptosis Regulatory Proteins; Cell Division; Cell Line, Tumor; Cell Survival; Coculture Techniques; Cytotoxicity Tests, Immunologic; Humans; Intracellular Membranes/physiology; Jurkat Cells; Ligands; Lymphocyte Activation; Melanoma/immunology; Melanoma/pathology; Membrane Potentials/drug effects; Microtubules/metabolism; Mitochondria/physiology; Phytohemagglutinins/pharmacology; Secretory Vesicles/drug effects; Secretory Vesicles/immunology; Secretory Vesicles/ultrastructure; T-Lymphocytes/immunology; TNF-Related Apoptosis-Inducing Ligand; alpha-MSH/pharmacology; fas Receptor/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / T-Lymphocytes / Tumor Necrosis Factor-alpha / Fas Receptor / Secretory Vesicles / Melanoma Limits: Humans Language: En Journal: Exp Cell Res Year: 2004 Document type: Article Affiliation country: Spain Country of publication: United States

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