Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate.

Lehmann, Kim P; Phillips, Suzanne; Sar, Madhabananda; Foster, Paul M D; Gaido, Kevin W

Lehmann, Kim P; Phillips, Suzanne; Sar, Madhabananda; Foster, Paul M D; Gaido, Kevin W.

Affiliation

Lehmann KP; CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA.

Toxicol Sci ; 81(1): 60-8, 2004 Sep.

Article in En | MEDLINE | ID: mdl-15141095

Subject(s)

Dibutyl Phthalate/toxicity; Gene Expression/drug effects; Testis/metabolism; Testosterone/biosynthesis; 3-Hydroxysteroid Dehydrogenases/biosynthesis; 3-Hydroxysteroid Dehydrogenases/genetics; Animals; Azo Compounds; Blotting, Western; Coloring Agents; Dose-Response Relationship, Drug; Female; Immunohistochemistry; Male; Phosphoproteins/biosynthesis; Phosphoproteins/genetics; Pregnancy; RNA/biosynthesis; RNA/genetics; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Steroid 17-alpha-Hydroxylase/biosynthesis; Steroid 17-alpha-Hydroxylase/genetics; Testis/drug effects; Testis/embryology

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Collection: 01-internacional Database: MEDLINE Main subject: Testis / Testosterone / Gene Expression / Dibutyl Phthalate Limits: Animals / Pregnancy Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States

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