In pneumococcal meningitis a novel water-soluble inhibitor of matrix metalloproteinases and TNF-alpha converting enzyme attenuates seizures and injury of the cerebral cortex.

Meli, D N; Loeffler, J M; Baumann, P; Neumann, U; Buhl, T; Leppert, D; Leib, S L

Meli, D N; Loeffler, J M; Baumann, P; Neumann, U; Buhl, T; Leppert, D; Leib, S L.

Affiliation

Meli DN; Institute for Infectious Diseases, University of Bern, Friedbühlstrasse 51, P.O. Box 61, 3010 Bern, Switzerland.

J Neuroimmunol ; 151(1-2): 6-11, 2004 Jun.

Article in En | MEDLINE | ID: mdl-15145598

Subject(s)

Cerebral Cortex/drug effects; Enzyme Inhibitors/pharmacology; Matrix Metalloproteinase Inhibitors; Meningitis, Pneumococcal/drug therapy; Metalloendopeptidases/antagonists & inhibitors; Seizures/drug therapy; ADAM Proteins; ADAM17 Protein; Animals; Animals, Newborn; Apoptosis/drug effects; Cerebral Cortex/injuries; Cerebral Cortex/pathology; Disease Models, Animal; Enzyme Activation/drug effects; Enzyme-Linked Immunosorbent Assay; Matrix Metalloproteinases/drug effects; Meningitis, Pneumococcal/complications; Metalloendopeptidases/drug effects; Rats; Rats, Sprague-Dawley; Seizures/etiology; Tumor Necrosis Factor-alpha/drug effects

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Metalloendopeptidases / Cerebral Cortex / Enzyme Inhibitors / Matrix Metalloproteinase Inhibitors / Meningitis, Pneumococcal Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Neuroimmunol Year: 2004 Document type: Article Affiliation country: Switzerland

Search on Google

Add to My VHL

XML

PubMed Links