Eucosterol-type nortriterpenoids from Merwilla natalensis.

Moodley, Nivan; Mulholland, Dulcie A; Crouch, Neil R

Moodley, Nivan; Mulholland, Dulcie A; Crouch, Neil R.

Affiliation

Moodley N; Natural Products Research Group, School of Pure and Applied Chemistry, University of KwaZulu-Natal, Durban 4041, South Africa.

J Nat Prod ; 67(5): 918-20, 2004 May.

Article in En | MEDLINE | ID: mdl-15165167

ABSTRACT

The bulbs of Merwilla natalensis have yielded two known homoisoflavanones, the known spirocyclic homoisoflavanone, scillascillin, four known nortriterpenoids, and the new nortriterpenoid, (22R,23S)-17alpha,23-epoxy-22,29-dihydroxy-27-nor-lanost-8-en-3,24-dione (1), bisnortriterpenoid, (22R,23S)-17alpha,23-epoxy-3beta,22,24xi-trihydroxy-27,28-bisnor-lanost-8-ene (2), and trisnortriterpenoid, (23S)-17alpha,23-epoxy-3beta,24xi-dihydroxy-27,28,29-trisnor-lanost-8-ene (3). The structures of 1-3 were determined by spectroscopic methods.

Subject(s)

Lanosterol/analogs & derivatives; Lanosterol/chemistry; Lanosterol/isolation & purification; Liliaceae/chemistry; Plants, Medicinal/chemistry; Triterpenes/chemistry; Triterpenes/isolation & purification; Molecular Structure; Plant Roots/chemistry; South Africa; Stereoisomerism

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Collection: 01-internacional Database: MEDLINE Main subject: Plants, Medicinal / Triterpenes / Liliaceae / Lanosterol Country/Region as subject: Africa Language: En Journal: J Nat Prod Year: 2004 Document type: Article Affiliation country: South Africa Country of publication: United States

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