Microcionamides A and B, bioactive peptides from the philippine sponge Clathria (Thalysias) abietina.
J Org Chem
; 69(12): 4170-6, 2004 Jun 11.
Article
in En
| MEDLINE
| ID: mdl-15176844
ABSTRACT
Microcionamides A (1) and B (2) have been isolated from the Philippine marine sponge Clathria (Thalysias) abietina. These new linear peptides are cyclized via a cystine moiety and have their C-terminus blocked by a 2-phenylethylenamine group. Their total structures, including absolute stereochemistry, were determined by a combination of spectral and chemical methods. Compound 1 was shown to slowly isomerize about the C-36/C-37 double bond when stored in DMSO. Microcionamides A (1) and B (2) exhibited significant cytotoxicity against the human breast tumor cells lines MCF-7 and SKBR-3 and displayed inhibitory activity against Mycobacterium tuberculosis H(37)Ra.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides, Cyclic
/
Porifera
/
Anti-Bacterial Agents
/
Antineoplastic Agents
Limits:
Animals
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
J Org Chem
Year:
2004
Document type:
Article
Affiliation country:
United States