Studies on medicinal plants of Ivory Coast: investigation of Sida acuta for in vitro antiplasmodial activities and identification of an active constituent.
Phytomedicine
; 11(4): 338-41, 2004.
Article
in En
| MEDLINE
| ID: mdl-15185848
ABSTRACT
Sida acuta Burm. (Malvaceae) originating from Ivory Coast was selected after an ethnobotanical survey traditional healers of malaria commonly used this plant for the treatment. Extracts were tested on two strains of Plasmodium falciparum FcM29-Cameroon (chloroquine-resistant strain) and a Nigerian chloroquine-sensitive strain. Extracts were obtained by preparing decoction in water of the powdered plant, the technique used by most of the traditional healers. An ethanol extract was then made and tested. The IC50 values obtained for these extracts ranged from 3.9 to -5.4 microg/ml. Purification of this active fraction led to the identification of cryptolepine as the active antiplasmodial constituent of the plant.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmodium falciparum
/
Plant Extracts
/
Malaria, Falciparum
/
Malvaceae
/
Phytotherapy
/
Antimalarials
Type of study:
Diagnostic_studies
Limits:
Animals
Country/Region as subject:
Africa
Language:
En
Journal:
Phytomedicine
Journal subject:
TERAPIAS COMPLEMENTARES
Year:
2004
Document type:
Article
Affiliation country:
France