Tau gene and Parkinson's disease: a case-control study and meta-analysis.
J Neurol Neurosurg Psychiatry
; 75(7): 962-5, 2004 Jul.
Article
in En
| MEDLINE
| ID: mdl-15201350
ABSTRACT
OBJECTIVE:
To investigate whether the tau H1 haplotype is a genetic risk factor in Parkinson's disease and to report a meta-analysis on all previously published dataMETHODS:
andresults:
In a sample of 580 patients with Parkinson's disease and 513 controls there was an increased risk of Parkinson's disease for both the tau H1 haplotype (pCONCLUSIONS:
Homozygosity for the tau H1 is associated with an increased risk of Parkinson's disease. This adds to the growing body of evidence that common genetic variation contributes to the pathogenesis of this disorder.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Tau Proteins
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Neurol Neurosurg Psychiatry
Year:
2004
Document type:
Article
Affiliation country:
United kingdom
Country of publication:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM