In-vitro and in-vivo evaluation of mesalazine-guar gum matrix tablets for colonic drug delivery.
J Drug Target
; 12(2): 105-12, 2004 Feb.
Article
in En
| MEDLINE
| ID: mdl-15203904
ABSTRACT
The aim of this study was to develop colon-specific delivery systems for mesalazine (5-ASA) using guar gum as a carrier. A colon specific matrix tablet of mesalazine with guar gum was evaluated by in vitro and in vivo X-ray studies in humans. Two different types of guar gum were used in the experiments. Tablets were prepared by the slugging method. The physical properties of tablets were tested and in vitro release studies were performed by a flow-through cell apparatus with and without galactomannanase enzyme. The type and the amount of guar gum affected the in vitro release of drug from the matrix tablets. High viscosity guar gum, in the form of a matrix tablet was capable of protecting the drug from being released in the upper region of gastrointestinal (GI) system, i.e. stomach and small intestine. X-ray imaging technique was used to monitor the tablets throughout the GI system on 8 healthy volunteers. Barium sulphate was used as a marker in the tablets for in vivo studies. These results showed that, the matrix tablets reached the colon; not being subjected to disintegration in the upper region of the GI system in all the subjects.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Carriers
/
Anti-Inflammatory Agents, Non-Steroidal
/
Drug Delivery Systems
/
Mesalamine
/
Lower Gastrointestinal Tract
/
Galactans
/
Mannans
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Drug Target
Journal subject:
FARMACOLOGIA
Year:
2004
Document type:
Article
Affiliation country:
Turkey