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The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters.
Polli, Joseph W; Baughman, Todd M; Humphreys, Joan E; Jordan, Kelly H; Mote, Angela L; Webster, Lindsey O; Barnaby, Robert J; Vitulli, Giovanni; Bertolotti, Luigina; Read, Kevin D; Serabjit-Singh, Cosette J.
Affiliation
  • Polli JW; GlaxoSmithKline, Inc., P.O. Box 13398, Room: MAI.A2213, Research Triangle Park, NC 27709, USA. joseph.w.polli@gsk.com
Drug Metab Dispos ; 32(7): 722-6, 2004 Jul.
Article in En | MEDLINE | ID: mdl-15205387
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Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Receptors, N-Methyl-D-Aspartate / ATP Binding Cassette Transporter, Subfamily B, Member 1 / ATP-Binding Cassette Transporters / Indoles Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States
Search on Google
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Receptors, N-Methyl-D-Aspartate / ATP Binding Cassette Transporter, Subfamily B, Member 1 / ATP-Binding Cassette Transporters / Indoles Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States