Effects of secretin on extracellular amino acid concentrations in rat hippocampus.
J Neural Transm (Vienna)
; 111(7): 931-9, 2004 Jul.
Article
in En
| MEDLINE
| ID: mdl-15206007
ABSTRACT
In 1998, Horvath et al. (1998) observed a marked improvement in speech, eye contact, and attention in autistic children five weeks after treatment with secretin, which ocurred in the course of an endoscopic investigation. Since autism is hypothesized to be a hypoglutamatergic disorder we investigated the in vivo effects of secretin on extracellular amino acids in the rat brain. Studies were carried out on freely moving rats with microdialysis probes in the hippocampus. Amino acids were examined using tandem mass spectroscopy and HPLC/fluorometric detection. Following secretin injection (8.7 microg/kg i.p.), considerable increases in microdialysate glutamate and gamma-aminobutyric acid (GABA) levels were observed; other amino acids were not affected. The observed increased microdialysate concentrations of glutamate and GABA following secretin application may explain the results of the Horvath study.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Secretin
/
Extracellular Fluid
/
Amino Acids
/
Hippocampus
Limits:
Animals
Language:
En
Journal:
J Neural Transm (Vienna)
Year:
2004
Document type:
Article
Affiliation country:
Germany
Country of publication:
AT
/
AUSTRIA
/
ÁUSTRIA