An integrative biology approach for analysis of drug action in models of human vascular inflammation.

Kunkel, Eric J; Dea, Marlene; Ebens, Allen; Hytopoulos, Evangelos; Melrose, Jennifer; Nguyen, Dat; Ota, Ken S; Plavec, Ivan; Wang, Yuker; Watson, Susan R; Butcher, Eugene C; Berg, Ellen L

Kunkel, Eric J; Dea, Marlene; Ebens, Allen; Hytopoulos, Evangelos; Melrose, Jennifer; Nguyen, Dat; Ota, Ken S; Plavec, Ivan; Wang, Yuker; Watson, Susan R; Butcher, Eugene C; Berg, Ellen L.

Affiliation

Kunkel EJ; BioSeek, Inc., Burlingame, California 94010, USA.

FASEB J ; 18(11): 1279-81, 2004 Aug.

Article in En | MEDLINE | ID: mdl-15208272

Subject(s)

Drug Evaluation, Preclinical/methods; Endothelial Cells/drug effects; Endothelium, Vascular/drug effects; Leukocytes, Mononuclear/drug effects; Vasculitis/drug therapy; Anti-Inflammatory Agents/pharmacology; Cells, Cultured/drug effects; Coculture Techniques; Cytokines/antagonists & inhibitors; Drug Design; Endothelium, Vascular/cytology; Enzyme Inhibitors/pharmacology; Enzyme-Linked Immunosorbent Assay; Humans; Immunosuppressive Agents/pharmacology; Models, Biological; Pharmaceutical Preparations/classification; RNA, Small Interfering/pharmacology; Transfection; Umbilical Veins

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Collection: 01-internacional Database: MEDLINE Main subject: Vasculitis / Endothelium, Vascular / Leukocytes, Mononuclear / Endothelial Cells / Drug Evaluation, Preclinical Limits: Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2004 Document type: Article Affiliation country: United States

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