Your browser doesn't support javascript.
loading
Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.
J Med Chem ; 47(14): 3487-90, 2004 Jul 01.
Article in En | MEDLINE | ID: mdl-15214775
The effect of introducing hydrophobic groups onto the disaccharide portion of the mannopeptimycins has been examined. Under acid-catalyzed conditions dimethyl acetals and ketals react on the terminal mannose of the disaccharide moiety of mannopeptimycin-alpha and the cyclohexylalanyl analogue 2. The preferentially formed monofunctionalized 4,6-acetals and -ketals display potent antibacterial activities against Gram-positive microorganisms, including MRSA, PRSP, and VRE pathogens.
Subject(s)
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Glycopeptides / Gram-Positive Bacteria / Acetals / Anti-Bacterial Agents Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Glycopeptides / Gram-Positive Bacteria / Acetals / Anti-Bacterial Agents Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States