Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.

Kowa, Hisatomo; Sakakura, Tomoko; Matsuura, Yusuke; Wakabayashi, Tomoko; Mann, David M A; Duff, Karen; Tsuji, Shoji; Hashimoto, Tadafumi; Iwatsubo, Takeshi

Kowa, Hisatomo; Sakakura, Tomoko; Matsuura, Yusuke; Wakabayashi, Tomoko; Mann, David M A; Duff, Karen; Tsuji, Shoji; Hashimoto, Tadafumi; Iwatsubo, Takeshi.

Affiliation

Kowa H; Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Bunkyo-ku, Hongo, Tokyo 113-0033, Japan.

Am J Pathol ; 165(1): 273-81, 2004 Jul.

Article in En | MEDLINE | ID: mdl-15215182

Subject(s)

Amyloid beta-Peptides/metabolism; Membrane Proteins/metabolism; Non-Fibrillar Collagens; Peptide Fragments/metabolism; Plaque, Amyloid/chemistry; Thiazoles/metabolism; Adult; Aged; Aged, 80 and over; Alzheimer Disease/metabolism; Alzheimer Disease/pathology; Animals; Antibodies, Monoclonal/metabolism; Benzothiazoles; Down Syndrome/metabolism; Down Syndrome/pathology; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Male; Membrane Proteins/ultrastructure; Mice; Mice, Transgenic; Middle Aged; Neocortex/cytology; Neocortex/metabolism; Neocortex/pathology; Neurons/metabolism; Neurons/pathology; Plaque, Amyloid/ultrastructure; Tissue Distribution

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Thiazoles / Amyloid beta-Peptides / Plaque, Amyloid / Non-Fibrillar Collagens / Membrane Proteins Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Am J Pathol Year: 2004 Document type: Article Affiliation country: Japan Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google