Isobolographic analysis of the antinociceptive interactions of clonidine with nonsteroidal anti-inflammatory drugs.
Pharmacol Res
; 50(3): 273-8, 2004 Sep.
Article
in En
| MEDLINE
| ID: mdl-15225670
ABSTRACT
The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clonidine and each nonsteroidal anti-inflammatory drugs, when coadministered intraperitoneally and intrathecally (i.t.). The simultaneous intraperitoneal administration of fixed ratios of ED(50) fractions of all nonsteroidal anti-inflammatory drugs (naproxen, piroxicam, paracetamol, dipyrone or metamizol and nimesulide) combined with clonidine resulted in synergistic interactions. The same combinations administered intrathecally were additive. The synergistic interactions between systemic nonsteroidal anti-inflammatory drugs and clonidine may involve supraspinal mechanisms.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain Measurement
/
Anti-Inflammatory Agents, Non-Steroidal
/
Clonidine
/
Analgesics
Limits:
Animals
Language:
En
Journal:
Pharmacol Res
Journal subject:
FARMACOLOGIA
Year:
2004
Document type:
Article
Affiliation country:
Chile