Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.

Blizzard, Timothy A; DiNinno, Frank; Morgan, Jerry D; Chen, Helen Y; Wu, Jane Y; Gude, Candido; Kim, Seongkon; Chan, Wanda; Birzin, Elizabeth T; Tien Yang, Yi; Pai, Lee-Yuh; Zhang, Zhoupeng; Hayes, Edward C; DaSilva, Carolyn A; Tang, Wei; Rohrer, Susan P; Schaeffer, James M; Hammond, Milton L

Blizzard, Timothy A; DiNinno, Frank; Morgan, Jerry D; Chen, Helen Y; Wu, Jane Y; Gude, Candido; Kim, Seongkon; Chan, Wanda; Birzin, Elizabeth T; Tien Yang, Yi; Pai, Lee-Yuh; Zhang, Zhoupeng; Hayes, Edward C; DaSilva, Carolyn A; Tang, Wei; Rohrer, Susan P; Schaeffer, James M; Hammond, Milton L.

Affiliation

Blizzard TA; Merck Research Laboratories, Medicinal Chemistry, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com

Bioorg Med Chem Lett ; 14(15): 3861-4, 2004 Aug 02.

Article in En | MEDLINE | ID: mdl-15225685

Subject(s)

Bridged Bicyclo Compounds/chemistry; Ligands; Receptors, Estrogen/metabolism; Selective Estrogen Receptor Modulators/metabolism; Animals; Bridged Bicyclo Compounds/pharmacology; Female; Kinetics; Models, Molecular; Molecular Conformation; Selective Estrogen Receptor Modulators/chemistry; Selective Estrogen Receptor Modulators/pharmacology; Structure-Activity Relationship; Uterus/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Bridged Bicyclo Compounds / Receptors, Estrogen / Selective Estrogen Receptor Modulators / Ligands Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2004 Document type: Article Affiliation country: United States Country of publication: United kingdom

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