Synthesis and biological evaluation of analogues of butyrolactone I and molecular model of its interaction with CDK2.

Braña, Miguel F; García, M Luisa; López, Berta; de Pascual-Teresa, Beatriz; Ramos, Ana; Pozuelo, Jose M; Domínguez, M Teresa

Braña, Miguel F; García, M Luisa; López, Berta; de Pascual-Teresa, Beatriz; Ramos, Ana; Pozuelo, Jose M; Domínguez, M Teresa.

Affiliation

Braña MF; Departamento de CC Químicas, Facultad de CC, Experimentales y de la Salud, Universidad San Pablo CEU, Urb. Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain.

Org Biomol Chem ; 2(13): 1864-71, 2004 Jul 07.

Article in En | MEDLINE | ID: mdl-15227538

Subject(s)

4-Butyrolactone/analogs & derivatives; Models, Molecular; 4-Butyrolactone/chemical synthesis; 4-Butyrolactone/chemistry; 4-Butyrolactone/pharmacology; Binding Sites; Cell Line, Tumor; Cell Proliferation/drug effects; Esters/chemical synthesis; Esters/chemistry; Humans; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/chemistry; Protein Kinase Inhibitors/pharmacology; Protein Structure, Tertiary

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Collection: 01-internacional Database: MEDLINE Main subject: 4-Butyrolactone / Models, Molecular Limits: Humans Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2004 Document type: Article Affiliation country: Spain Country of publication: United kingdom

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