Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells.
Proc Natl Acad Sci U S A
; 101(29): 10685-90, 2004 Jul 20.
Article
in En
| MEDLINE
| ID: mdl-15243159
ABSTRACT
A group of T cells recognizes glycolipids presented by molecules of the CD1 family. The CD1d-restricted natural killer T cells (NKT cells) are primarily considered to be self-reactive. By employing CD1d-binding and T cell assays, the following structural parameters for presentation by CD1d were defined for a number of mycobacterial and mammalian lipids two acyl chains facilitated binding, and a polar head group was essential for T cell recognition. Of the mycobacterial lipids tested, only a phosphatidylinositol mannoside (PIM) fulfilled the requirements for CD1d binding and NKT cell stimulation. This PIM activated human and murine NKT cells via CD1d, thereby triggering antigen-specific IFN-gamma production and cell-mediated cytotoxicity, and PIM-loaded CD1d tetramers identified a subpopulation of murine and human NKT cells. This phospholipid, therefore, represents a mycobacterial antigen recognized by T cells in the context of CD1d.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphatidylinositols
/
Killer Cells, Natural
/
T-Lymphocytes
/
Lymphocyte Subsets
/
Antigens, CD1
/
Mycobacterium
/
Antigens, Bacterial
Limits:
Animals
/
Humans
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2004
Document type:
Article
Affiliation country:
Germany