Presence of angiotensin peptides in human urine.
Clin Chem
; 38(9): 1768-72, 1992 Sep.
Article
in En
| MEDLINE
| ID: mdl-1526012
ABSTRACT
Immunoreactive angiotensin I and angiotensin II were found in human urine that was purified on octadecasilylsilica cartridges. The daily excretion of angiotensin I and II in healthy volunteers was 189.00 (SE 38.36) and 17.54 (SE 3.07) pmol/24 h or 148.09 (SE 32.22) and 12.82 (SE 2.34) pmol/L, respectively (n = 12). No circadian rhythm was observed in the excretion patterns of angiotensin I and II. In vitro degradation of angiotensin I or II could not be detected in acidified urine samples. A marked increase in the excretion of angiotensin I and II could be demonstrated in patients with anaphylactoid reactions to drugs and food additives after oral challenge. Immunoreactive angiotensin I and II could be characterized by HPLC as Ile5-angiotensin I, Ile5-angiotensin II, and angiotensin II metabolites.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Angiotensin I
/
Angiotensin II
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Chem
Journal subject:
QUIMICA CLINICA
Year:
1992
Document type:
Article