Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone.

Benetton, S A; Borges, V M; Chang, T K H; McErlane, K M

Benetton, S A; Borges, V M; Chang, T K H; McErlane, K M.

Affiliation

Benetton SA; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

Xenobiotica ; 34(4): 335-44, 2004 Apr.

Article in En | MEDLINE | ID: mdl-15268978

Subject(s)

Cytochrome P-450 Enzyme System/chemistry; Cytochrome P-450 Enzyme System/metabolism; Hydromorphone/chemistry; Hydromorphone/metabolism; Microsomes, Liver/chemistry; Microsomes, Liver/enzymology; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System/genetics; Enzyme Activation; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/metabolism; Humans; Kinetics; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Cytochrome P-450 Enzyme System / Hydromorphone Type of study: Evaluation_studies Limits: Humans Language: En Journal: Xenobiotica Year: 2004 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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