Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375.

Schulz, Stefan; Mayer, Dana; Pfeiffer, Manuela; Stumm, Ralf; Koch, Thomas; Höllt, Volker

Schulz, Stefan; Mayer, Dana; Pfeiffer, Manuela; Stumm, Ralf; Koch, Thomas; Höllt, Volker.

Affiliation

Schulz S; Institut für Pharmakologie und Toxikologie, Otto-von-Guericke-Universität, Magdeburg, Germany. stefan.schulz@medizin.uni-magdeburg.de

EMBO J ; 23(16): 3282-9, 2004 Aug 18.

Article in En | MEDLINE | ID: mdl-15272312

Subject(s)

Morphine/pharmacology; Receptors, Opioid, mu/metabolism; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology; Humans; Mutation/genetics; Phosphorylation/drug effects; Phosphoserine/metabolism; Receptors, Opioid, mu/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Opioid, mu / Morphine Limits: Humans Language: En Journal: EMBO J Year: 2004 Document type: Article Affiliation country: Germany

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