Phosphatidylinositol 3-Kinases/metabolism; Prostatic Neoplasms/enzymology; Prostatic Neoplasms/pathology; Protein Kinase C/metabolism; Protein Serine-Threonine Kinases/metabolism; Protein-Tyrosine Kinases/metabolism; Animals; Basement Membrane/enzymology; Basement Membrane/metabolism; Basement Membrane/pathology; Catalysis; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Male; Mice; Mice, Knockout; PTEN Phosphohydrolase; Phosphatidylinositol 3-Kinases/genetics; Prostatic Neoplasms/genetics; Protein Kinase C/genetics; Protein Serine-Threonine Kinases/genetics; Protein Tyrosine Phosphatases/deficiency; Protein Tyrosine Phosphatases/genetics; Protein Tyrosine Phosphatases/metabolism; Protein-Tyrosine Kinases/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Signal Transduction; Tumor Suppressor Proteins/deficiency; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism; Up-Regulation