Indoor exposures and recurrent wheezing in infants: a study in the BAMSE cohort.
Acta Paediatr
; 93(7): 899-905, 2004 Jul.
Article
in En
| MEDLINE
| ID: mdl-15303804
ABSTRACT
AIM:
The aim of this study was to examine the relationship between indoor exposures and the home environment, and the development of recurrent wheezing during infancy.METHODS:
A birth cohort, comprising 4089 children, was followed. Information on exposures was obtained shortly after birth, and episodes of wheezing were recorded when the infants were 1 and 2 y of age. In a nested case-control study, 181 infants were enrolled, who had three or more reported episodes of wheezing after 3 mo of age combined with either use of inhaled steroids or symptoms of bronchial hyper-reactivity, and 359 age-matched controls. Home inspections were performed during the winter following enrolment, and indoor conditions were measured.RESULTS:
Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated. The OR for recurrent infant wheezing associated with signs of dampness reported prospectively by parents was 1.4 (0.9-2.2), and the OR for observed signs of dampness at home inspections was 1.6 (1.0-2.5). A trend was found in the risk of recurrent wheezing in relation to the number of indicators of dampness OR 1.3 (0.8-2.2) for one sign of dampness and OR 2.7 (1.3-5.4) for three or more signs of dampness. Newly painted surfaces in the child's bedroom was associated with an increased OR for recurrent wheezing 1.7 (1.3-2.6).CONCLUSION:
Indicators of dampness, as well as recently repainted interior surfaces, appear to be associated with recurrent infant wheezing, with a strengthened effect of combined indoor exposures.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory Sounds
/
Air Pollution, Indoor
/
Environmental Exposure
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Humans
/
Infant
Language:
En
Journal:
Acta Paediatr
Year:
2004
Document type:
Article
Affiliation country:
Sweden