Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome.

Taub, Jeffrey W; Mundschau, Gina; Ge, Yubin; Poulik, Janet M; Qureshi, Faisal; Jensen, Tanya; James, S Jill; Matherly, Larry H; Wechsler, Joshua; Crispino, John D

Taub, Jeffrey W; Mundschau, Gina; Ge, Yubin; Poulik, Janet M; Qureshi, Faisal; Jensen, Tanya; James, S Jill; Matherly, Larry H; Wechsler, Joshua; Crispino, John D.

Blood ; 104(5): 1588-9, 2004 Sep 01.

Article in En | MEDLINE | ID: mdl-15317736

Subject(s)

DNA-Binding Proteins/genetics; Down Syndrome/complications; Down Syndrome/genetics; Leukemia, Megakaryoblastic, Acute/complications; Leukemia, Megakaryoblastic, Acute/genetics; Transcription Factors/genetics; Erythroid-Specific DNA-Binding Factors; GATA1 Transcription Factor; Humans; Mutation

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Leukemia, Megakaryoblastic, Acute / Down Syndrome / DNA-Binding Proteins Limits: Humans Language: En Journal: Blood Year: 2004 Document type: Article

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