A Cyp1a2-luciferase transgenic CD-1 mouse model: responses to aryl hydrocarbons similar to the humanized AhR mice.

Zhang, Weisheng; Moorthy, Bhagavatula; Chen, Min; Muthiah, Kathirvel; Coffee, Richard; Purchio, Anthony F; West, David B

Zhang, Weisheng; Moorthy, Bhagavatula; Chen, Min; Muthiah, Kathirvel; Coffee, Richard; Purchio, Anthony F; West, David B.

Affiliation

Zhang W; Xenogen Corporation, 860 Atlantic Avenue, Alameda, CA 94501, USA. wzhang@xenogen.com

Toxicol Sci ; 82(1): 297-307, 2004 Nov.

Article in En | MEDLINE | ID: mdl-15329440

Subject(s)

Cytochrome P-450 CYP1A2/genetics; Gene Expression Regulation/drug effects; Hydrocarbons, Aromatic/toxicity; Luciferases/genetics; Mice, Transgenic; Models, Animal; Amino Acid Sequence; Animals; Animals, Outbred Strains; Cytochrome P-450 CYP1A2/biosynthesis; Female; Genes, Reporter/genetics; Humans; Luciferases/biosynthesis; Male; Mice; Molecular Sequence Data; Polymorphism, Genetic; RNA, Messenger/metabolism; Receptors, Aryl Hydrocarbon/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Mice, Transgenic / Gene Expression Regulation / Cytochrome P-450 CYP1A2 / Models, Animal / Hydrocarbons, Aromatic / Luciferases Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States

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