Open-access high-resolution mass spectrometry in early drug discovery.
J Mass Spectrom
; 39(8): 942-8, 2004 Aug.
Article
in En
| MEDLINE
| ID: mdl-15329846
ABSTRACT
Techniques such as mass spectrometry and NMR spectroscopy form an essential part of the medicinal chemist's toolbox for characterizing and assessing the purity of new molecules. Empowering medicinal chemists to gain early insight into their reaction products has a direct impact on productivity. Devolution of cutting-edge techniques from the specialist to the bench chemist also frees the specialist to concentrate on solving the more demanding of analytical problems. For open-access techniques to be taken up, they must be robust and be able to handle differing sample concentrations and varying sample complexities. This paper details the implementation of high-resolution liquid chromatography/mass spectrometry in open access to aid the medicinal chemist in characterizing desired products and identifying unexpected rearrangements, by-products and complete unknowns.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pharmaceutical Preparations
/
Chemistry, Pharmaceutical
/
Spectrometry, Mass, Electrospray Ionization
/
Drug Evaluation, Preclinical
Type of study:
Evaluation_studies
Limits:
Humans
Language:
En
Journal:
J Mass Spectrom
Year:
2004
Document type:
Article
Affiliation country:
United kingdom