Simultaneous injection of hepatitis B vaccine with BCG and killed poliovirus vaccine.
Vaccine
; 10(5): 319-21, 1992.
Article
in En
| MEDLINE
| ID: mdl-1533479
ABSTRACT
In most developing countries, hepatitis B virus is endemic and prevention has to be carried out early in life and on a mass scale. In these regions, simultaneous administration of multiple antigens is normal practice. We have therefore investigated the interaction of hepatitis B vaccine with BCG and inactivated polio vaccine. The serological antibody response to poliovirus and HBsAg as well as the cellular immune response to tuberculin post BCG immunization were assessed. The immune responses to HBsAg, BCG and polio vaccines injected simultaneously were comparable to those observed after separate administration of each vaccine. Moreover, no increase of adverse reactions was noted. Results confirmed that HB vaccine could be introduced into the WHO expanded programmes on immunization without impairing the expected protective efficacy against the targeted vaccine-preventable diseases.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
BCG Vaccine
/
Viral Hepatitis Vaccines
/
Poliovirus Vaccine, Inactivated
Type of study:
Clinical_trials
Limits:
Humans
/
Newborn
Language:
En
Journal:
Vaccine
Year:
1992
Document type:
Article
Affiliation country:
France