Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists.

Chen, Chen; Wilcoxen, Keith M; Huang, Charles Q; Xie, Yun-Feng; McCarthy, James R; Webb, Thomas R; Zhu, Yun-Fei; Saunders, John; Liu, Xin-Jun; Chen, Ta-Kung; Bozigian, Haig; Grigoriadis, Dimitri E

Chen, Chen; Wilcoxen, Keith M; Huang, Charles Q; Xie, Yun-Feng; McCarthy, James R; Webb, Thomas R; Zhu, Yun-Fei; Saunders, John; Liu, Xin-Jun; Chen, Ta-Kung; Bozigian, Haig; Grigoriadis, Dimitri E.

Affiliation

Chen C; Neurocrine Biosciences, Inc., 10555 Sciences Center Drive, San Diego, California 92121, USA. cchen@neurocrine.com

J Med Chem ; 47(19): 4787-98, 2004 Sep 09.

Article in En | MEDLINE | ID: mdl-15341493

Subject(s)

Drug Design; Pyrimidines/chemistry; Pyrimidines/pharmacology; Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors; Adrenocorticotropic Hormone/metabolism; Animals; Corticotropin-Releasing Hormone/pharmacology; Cyclic AMP/metabolism; Inhibitory Concentration 50; Male; Mice; Molecular Structure; Pyrimidines/administration & dosage; Pyrimidines/chemical synthesis; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Drug Design / Receptors, Corticotropin-Releasing Hormone Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States

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