The effects of modifying in vivo cytochrome P450 3A (CYP3A) activity on etoricoxib pharmacokinetics and of etoricoxib administration on CYP3A activity.

Agrawal, Nancy G B; Matthews, Catherine Z; Mazenko, Ralph S; Woolf, Eric J; Porras, Arturo G; Chen, Xun; Miller, Jutta L; Michiels, Nicole; Wehling, Martin; Schultz, Armin; Gottlieb, Alice B; Kraft, Walter K; Greenberg, Howard E; Waldman, Scott A; Curtis, Sean P; Gottesdiener, Keith M

Agrawal, Nancy G B; Matthews, Catherine Z; Mazenko, Ralph S; Woolf, Eric J; Porras, Arturo G; Chen, Xun; Miller, Jutta L; Michiels, Nicole; Wehling, Martin; Schultz, Armin; Gottlieb, Alice B; Kraft, Walter K; Greenberg, Howard E; Waldman, Scott A; Curtis, Sean P; Gottesdiener, Keith M.

Affiliation

Agrawal NG; Merck Research Laboratories, West Point, PA 19486, USA.

J Clin Pharmacol ; 44(10): 1125-31, 2004 Oct.

Article in En | MEDLINE | ID: mdl-15342613

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Pyridines/administration & dosage; Pyridines/pharmacokinetics; Sulfones/administration & dosage; Sulfones/pharmacokinetics; Adult; Analysis of Variance; Confidence Intervals; Cross-Over Studies; Cytochrome P-450 CYP3A; Enzyme Activation/drug effects; Enzyme Activation/physiology; Etoricoxib; Female; Humans; Male; Pyridines/blood; Sulfones/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Sulfones / Cytochrome P-450 Enzyme System Type of study: Clinical_trials Limits: Adult / Female / Humans / Male Language: En Journal: J Clin Pharmacol Year: 2004 Document type: Article Affiliation country: United States Country of publication: United kingdom

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