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Switching on kinases: oncogenic activation of BRAF and the PDGFR family.
Dibb, Nick J; Dilworth, Stephen M; Mol, Clifford D.
Affiliation
  • Dibb NJ; Institute of Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, London W12 ONN, UK. n.dibb@imperial.ac.uk
Nat Rev Cancer ; 4(9): 718-27, 2004 09.
Article in En | MEDLINE | ID: mdl-15343278
ABSTRACT
The cytoplasmic serine/threonine kinase BRAF and receptor tyrosine kinases of the platelet-derived growth factor receptor (PDGFR) family are frequently activated in cancer by mutations of an equivalent amino acid. Structural studies have provided important insights into why these very different kinases share similar oncogenic hot spots and why the PDGFR juxtamembrane region is also a frequent oncogenic target. This research has implications for other kinases that are mutated in human tumours and for the treatment of cancer using kinase inhibitors.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Receptors, Platelet-Derived Growth Factor / Proto-Oncogene Proteins c-raf Limits: Humans Language: En Journal: Nat Rev Cancer Journal subject: NEOPLASIAS Year: 2004 Document type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Receptors, Platelet-Derived Growth Factor / Proto-Oncogene Proteins c-raf Limits: Humans Language: En Journal: Nat Rev Cancer Journal subject: NEOPLASIAS Year: 2004 Document type: Article Affiliation country: United kingdom