Bioaerosols and innate immune responses in airway diseases.
Curr Opin Allergy Clin Immunol
; 4(5): 361-6, 2004 Oct.
Article
in En
| MEDLINE
| ID: mdl-15349034
ABSTRACT
PURPOSE OF REVIEW We review the role of bioaerosols in the pathogenesis of inflammatory airway disease. The focus is on recent discoveries in innate immune responses induced by common components of bioaerosols. RECENT FINDINGS:
Common components of bioaerosols include endotoxin, peptidoglycan and beta-glucan; all of which have been associated with inflammatory airway disease. Endotoxin signaling through toll-like receptor 4 is well characterized and updated. Peptidoglycan is now known to signal through three types of molecules toll-like receptor 2; peptidoglycan recognition proteins; and nucleotide-binding oligomerization domain molecules. Beta-glucan, a common fungal cell wall component, signals through the newly discovered receptor, dectin-1. Emerging data indicate that genetic polymorphisms influence the response to bioaerosols.SUMMARY:
Activation of the innate immune system by bioaerosols is becoming better understood. This knowledge provides an opportunity to better prevent and treat airway diseases that result from environmental exposure.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonia
/
Aerosols
/
Air Pollutants
Limits:
Humans
Language:
En
Journal:
Curr Opin Allergy Clin Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2004
Document type:
Article
Affiliation country:
United States
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA