Synthesis of polyhydroxylated piperidines and evaluation as glycosidase inhibitors.
Bioorg Med Chem
; 12(19): 5091-7, 2004 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-15351392
ABSTRACT
A series of 16 new chiral nonracemic polyhydroxylated piperidines was synthesized utilizing several chiral beta-amino-alcohols. They act as a nitrogen source, chirality inducer and iminium stabilizer, in the desymmetrization of meso-trihydroxylated glutaraldehyde. The biological activity of these compounds towards several glycosidases (alpha-D-glucosidase, alpha-D-mannosidase, alpha-L-fucosidase) has been evaluated.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Piperidines
/
Glycoside Hydrolases
Language:
En
Journal:
Bioorg Med Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2004
Document type:
Article
Affiliation country:
France
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM