Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists.

Rijkers, Dirk T S; den Hartog, Jack A J; Liskamp, Rob M J

Rijkers, Dirk T S; den Hartog, Jack A J; Liskamp, Rob M J.

Affiliation

Rijkers DT; Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands. d.t.s.rijkers@pharm.uu.nl <d.t.s.rijkers@pharm.uu.nl>

Bioorg Med Chem ; 12(19): 5099-106, 2004 Oct 01.

Article in En | MEDLINE | ID: mdl-15351393

Subject(s)

Corticotropin-Releasing Hormone/antagonists & inhibitors; Corticotropin-Releasing Hormone/chemical synthesis; Peptide Fragments/chemical synthesis; Animals; Cell Line; Corticotropin-Releasing Hormone/chemistry; Corticotropin-Releasing Hormone/pharmacology; Cyclic AMP/biosynthesis; Fluorescent Dyes/chemistry; Lipids/chemistry; Peptide Fragments/chemistry; Peptide Fragments/pharmacology; Rats; Receptors, Corticotropin-Releasing Hormone; Structure-Activity Relationship; beta-Galactosidase/analysis; beta-Galactosidase/biosynthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Corticotropin-Releasing Hormone Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2004 Document type: Article

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