Primary Sjögren's syndrome complicated with cryoglobulinemic glomerulonephritis, myocarditis, and multi-organ involvement.
J Formos Med Assoc
; 103(9): 707-10, 2004 Sep.
Article
in En
| MEDLINE
| ID: mdl-15361944
ABSTRACT
Glomerulonephritis in primary Sjögren's syndrome is rarely reported. Cryoglobulinemic glomerulonephritis with the presence of cryoglobulin deposition in the glomerular capillary lumen in primary Sjögren's syndrome is extremely rare. A 51-year-old woman with primary Sjögren's syndrome for > 10 years complained of fever, hypertension, and proteinuria. In addition, novel manifestations, including myocarditis with heart failure, pericardial effusion, and polyneuropathy (sensory motor neuropathy) were also noted. Cryoglobulinemia test was positive, and kidney biopsy results were consistent with cryoglobulinemic glomerulonephritis. There were no symptoms associated with systemic lupus erythematosus or other connective tissue disease. Treatment with monthly methylprednisolone and cyclophosphamide pulse therapy for 6 months resulted in resolution of proteinuria, heart failure, and neurologic symptoms.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sjogren's Syndrome
/
Cryoglobulinemia
/
Glomerulonephritis
/
Myocarditis
Type of study:
Etiology_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
J Formos Med Assoc
Journal subject:
MEDICINA
Year:
2004
Document type:
Article
Affiliation country:
Taiwan