Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model.
Eur J Pharmacol
; 498(1-3): 287-94, 2004 Sep 13.
Article
in En
| MEDLINE
| ID: mdl-15364007
ABSTRACT
In this study, we investigated the involvement of neurokinin NK3 receptors in a severe asthma model prepared by administering ovalbumin via inhalation three times to systemically sensitized guinea pigs. [3H]senktide, a neurokinin NK3 receptor ligand, showed significant specific binding to the lungs from the model animals, but not to those from negative control animals. The airway responsiveness to intravenous neurokinin B, a neurokinin NK3 receptor agonist, was increased in the model, indicating an increase in functional NK3 receptors. Furthermore, SB 223956 ((-)-3-methoxy-2-phenyl-N-[(1S)-phenylpropyl]quinoline-4-carboxamide), a selective neurokinin NK3 receptor antagonist, significantly inhibited the ovalbumin-induced airway hyperresponsiveness to inhaled methacholine, but it did not show significant effects on the ovalbumin-induced airway narrowing and eosinophil accumulation. These results suggest that the expressed neurokinin NK3 receptors in the severe asthma model are involved in the development of airway hyperresponsiveness.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Substance P
/
Receptors, Neurokinin-3
Limits:
Animals
Language:
En
Journal:
Eur J Pharmacol
Year:
2004
Document type:
Article
Affiliation country:
Japan