Malignant tumor formation in dogs previously irradiated for acanthomatous epulis.
Vet Radiol Ultrasound
; 45(4): 357-61, 2004.
Article
in En
| MEDLINE
| ID: mdl-15373265
ABSTRACT
In this retrospective study of 57 dogs irradiated for oral acanthomatous epulis, 2 (3.5%) dogs developed a second tumor (sarcoma, osteosarcoma) in the radiation treatment field at 5.2 and 8.7 years after the end of radiation therapy. As opposed to previous reports, no second epithelial tumors developed in the radiation treatment field. There is a risk of radiation-induced carcinogenesis, but it appears that it is a relatively low risk and an event that occurs years after radiation therapy. Radiation-induced tumors are of more concern in younger dogs that undergo radiation therapy for tumors that are radioresponsive, such as acanthomatous epulis, where long-term survival is expected. The only statistically significant variable in the survival analysis was age, with dogs less than 8.3 years old having a significantly longer median overall survival (2322 days) than dogs older than 8.3 years (1106 days; P<0.0001).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mouth Neoplasms
/
Dog Diseases
/
Gingival Hyperplasia
/
Neoplasms, Radiation-Induced
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Animals
Country/Region as subject:
America do norte
Language:
En
Journal:
Vet Radiol Ultrasound
Journal subject:
DIAGNOSTICO POR IMAGEM
/
MEDICINA VETERINARIA
/
RADIOLOGIA
Year:
2004
Document type:
Article
Affiliation country:
United States