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Malignant tumor formation in dogs previously irradiated for acanthomatous epulis.
McEntee, Margaret C; Page, Rodney L; Théon, Alain; Erb, Hollis N; Thrall, Donald E.
Affiliation
  • McEntee MC; Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. mcm43@cornell.edu
Vet Radiol Ultrasound ; 45(4): 357-61, 2004.
Article in En | MEDLINE | ID: mdl-15373265
ABSTRACT
In this retrospective study of 57 dogs irradiated for oral acanthomatous epulis, 2 (3.5%) dogs developed a second tumor (sarcoma, osteosarcoma) in the radiation treatment field at 5.2 and 8.7 years after the end of radiation therapy. As opposed to previous reports, no second epithelial tumors developed in the radiation treatment field. There is a risk of radiation-induced carcinogenesis, but it appears that it is a relatively low risk and an event that occurs years after radiation therapy. Radiation-induced tumors are of more concern in younger dogs that undergo radiation therapy for tumors that are radioresponsive, such as acanthomatous epulis, where long-term survival is expected. The only statistically significant variable in the survival analysis was age, with dogs less than 8.3 years old having a significantly longer median overall survival (2322 days) than dogs older than 8.3 years (1106 days; P<0.0001).
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Mouth Neoplasms / Dog Diseases / Gingival Hyperplasia / Neoplasms, Radiation-Induced Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Animals Country/Region as subject: America do norte Language: En Journal: Vet Radiol Ultrasound Journal subject: DIAGNOSTICO POR IMAGEM / MEDICINA VETERINARIA / RADIOLOGIA Year: 2004 Document type: Article Affiliation country: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Mouth Neoplasms / Dog Diseases / Gingival Hyperplasia / Neoplasms, Radiation-Induced Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Animals Country/Region as subject: America do norte Language: En Journal: Vet Radiol Ultrasound Journal subject: DIAGNOSTICO POR IMAGEM / MEDICINA VETERINARIA / RADIOLOGIA Year: 2004 Document type: Article Affiliation country: United States