Novel method for studying myelination in vivo reveals that EDTA is a potent inhibitor of myelin protein and mRNA expression during development of the rat sciatic nerve.

Meintanis, Stathis; Thomaidou, Dimitra; Jessen, Kristjan R; Mirsky, Rhona; Matsas, Rebecca

Meintanis, Stathis; Thomaidou, Dimitra; Jessen, Kristjan R; Mirsky, Rhona; Matsas, Rebecca.

Affiliation

Meintanis S; Department of Biochemistry, Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 115 21 Athens, Greece.

Glia ; 48(2): 132-44, 2004 Nov 01.

Article in En | MEDLINE | ID: mdl-15378656

Subject(s)

Drug Carriers/administration & dosage; Edetic Acid/pharmacology; Myelin Proteins/genetics; Myelin Sheath/drug effects; Sciatic Nerve/drug effects; Silicone Elastomers/administration & dosage; Animals; Animals, Newborn; Chelating Agents/pharmacology; DNA-Binding Proteins/genetics; Disease Models, Animal; Down-Regulation/drug effects; Down-Regulation/genetics; Early Growth Response Protein 2; Galactosylceramides/genetics; Growth Inhibitors/pharmacology; Implants, Experimental; Microscopy, Electron, Transmission; Myelin Basic Protein/genetics; Myelin P0 Protein/genetics; Myelin Sheath/metabolism; Myelin Sheath/ultrastructure; Nerve Regeneration/drug effects; Nerve Regeneration/genetics; Neurosurgical Procedures/instrumentation; Neurosurgical Procedures/methods; RNA, Messenger/drug effects; RNA, Messenger/metabolism; Rats; Schwann Cells/drug effects; Schwann Cells/metabolism; Sciatic Nerve/growth & development; Sciatic Nerve/ultrastructure; Transcription Factors/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Sciatic Nerve / Silicone Elastomers / Drug Carriers / Edetic Acid / Myelin Proteins / Myelin Sheath Type of study: Prognostic_studies Limits: Animals Language: En Journal: Glia Journal subject: NEUROLOGIA Year: 2004 Document type: Article Affiliation country: Greece Country of publication: United States

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