Current smoking and response to cholinesterase inhibitor therapy in Alzheimer's disease.
Dement Geriatr Cogn Disord
; 19(1): 11-4, 2005.
Article
in En
| MEDLINE
| ID: mdl-15383739
ABSTRACT
Current smoking has been suggested as predicting poor response to cholinesterase inhibitor treatment. This observational study compares response in subjects with NINCDS-ADRDA 'probable' Alzheimer's disease who are current smokers and subjects who are non-smokers. Smoking status was not associated with response. Smokers were significantly more likely to improve Digit Symbol Substitution Test (DSST) scores following treatment. In non-smokers, improvement from baseline DSST scores was associated with good response but this was not the case in smokers. The change in the DSST is in keeping with smokers having increased numbers of nicotinic receptors. In smokers, the lack of association between improvement in DSST scores and good response may be representative of inhibitory properties of cigarette smoke that are unrelated to nicotine.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Smoking
/
Cholinesterase Inhibitors
/
Alzheimer Disease
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Dement Geriatr Cogn Disord
Journal subject:
GERIATRIA
/
NEUROLOGIA
/
PSIQUIATRIA
Year:
2005
Document type:
Article
Affiliation country:
United kingdom